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ea0099p236 | Adrenal and Cardiovascular Endocrinology | ECE2024

Impact of environmental pollution on adrenocortical carcinoma in Italy

Puglisi Soraya , Calabrese Anna , Ferrau Francesco , Alessi Ylenia , Lagana Marta , Grisanti Salvatore , Ceccato Filippo , Scaroni Carla , Di Dalmazi Guido , Stigliano Antonio , Altieri Barbara , Canu Letizia , Luconi Michaela , Loli Paola , DeMartino Maria Cristina , Arvat Emanuela , Palmieri Serena , Perotti Paola , Basile Vittoria , Berchialla Paola , Berruti Alfredo , Pia Anna , Reimondo Giuseppe , Cannavo Salvatore , Terzolo Massimo

Background: Whether environmental pollution may influence adrenocortical carcinoma (ACC) development remains largely unknown. The aim of this study was to evaluate the impact of exposition to environmental pollutants on ACC presentation and prognosis in Italy.Patients and methods: A retrospective analysis was done on 500 patients affected by ACC, who were diagnosed in 12 reference centers in Italy from 1990 to 2018 and followed-up for a median of 37.5 mo...